Compare Peptides

Select any two compounds for a side-by-side comparison of mechanism, uses, risks, and FDA regulatory status.

Popular comparisons

GHRP-2

Growth Hormone Releasing Peptide-2, Pralmorelin

Unregulated
Growth Hormone Secretagogue

CJC-1295

CJC-1295 with DAC, CJC-1295 no DAC

Category 1
Growth Hormone Secretagogue
Overview

A synthetic hexapeptide growth hormone secretagogue that stimulates GH release through the ghrelin receptor. Considered one of the most potent GHRPs available, producing stronger GH pulses than GHRP-6 but with more appetite stimulation than ipamorelin. Widely used in anti-aging and performance contexts.

A synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates the pituitary gland to produce more growth hormone. Available with or without a Drug Affinity Complex (DAC) that extends its half-life.

Mechanism of Action

Binds to the growth hormone secretagogue receptor (GHS-R1a / ghrelin receptor) in the anterior pituitary, triggering GH release. Also stimulates appetite through hypothalamic ghrelin pathways. Produces a robust GH pulse that synergizes with GHRH analogs like CJC-1295 or sermorelin.

Binds to GHRH receptors on the pituitary gland, stimulating pulsatile release of growth hormone. The DAC version binds to albumin in the blood, extending the half-life from minutes to approximately 6-8 days.

Common Uses
  • Growth hormone optimization
  • Muscle growth and recovery
  • Anti-aging protocols
  • Improved sleep quality
  • Fat loss (via elevated GH)
  • Growth hormone optimization
  • Improved sleep quality
  • Fat loss
  • Muscle recovery
  • Anti-aging protocols
Known Risks
  • Increased appetite and hunger
  • Water retention
  • Elevated cortisol and prolactin (dose-dependent)
  • Tingling or numbness at injection site
  • Potential blood sugar effects
  • Water retention
  • Tingling or numbness
  • Potential cortisol elevation
  • Limited long-term safety data
  • May affect blood sugar levels
Regulatory Status
Unregulated

Not FDA-approved. Available as a research chemical. Pralmorelin (the INN name) has been studied clinically in Japan for GH deficiency diagnosis but has no approved therapeutic indication in the US.

Category 1

Reclassified to Category 1 in February 2026 as part of the HHS announcement restoring compounding access. Not affected by the April 15, 2026 Category 2 removal action. Available through licensed 503A compounding pharmacies with a physician prescription.

This comparison is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy.