Calcitonin
FDA ApprovedAlso known as: Miacalcin, Fortical, Salmon Calcitonin
Bone & MetabolicLast reviewed: April 28, 2026
A 32-amino acid peptide hormone produced by the thyroid gland that regulates calcium and bone metabolism. The salmon-derived form (sCT) is FDA-approved for osteoporosis and Paget's disease. One of the earliest peptide drugs.
Mechanism of Action
Binds to calcitonin receptors on osteoclasts, directly inhibiting bone resorption. Also has analgesic properties for bone pain through central nervous system mechanisms that are not fully understood. Salmon calcitonin is 40-50x more potent than human calcitonin.
Common Uses
- Postmenopausal osteoporosis
- Paget's disease of bone
- Hypercalcemia of malignancy
- Bone pain relief
Known Risks
- Nasal irritation (nasal spray)
- Nausea
- Flushing
- Possible increased cancer risk with long-term use (FDA warning)
- Antibody formation reducing efficacy over time
Regulatory Status
FDA-approved as Miacalcin (injection, 1986; nasal spray, 1995) and Fortical (nasal spray). Largely superseded by bisphosphonates and newer agents for osteoporosis but still used for acute bone pain and Paget's disease.
Common Protocols
Protocol information is for educational reference only. Dosing varies significantly by individual, condition, and physician guidance. Always work with a licensed healthcare provider.
Intranasal spray
Typical Dose
200 IU
Frequency
Once daily (alternating nostrils)
Cycle Length
Ongoing
Most common form. Alternate nostrils daily. Store upright at room temperature. Prime pump before first use.
Subcutaneous/Intramuscular injection
Typical Dose
100 IU
Frequency
Once daily or every other day
Cycle Length
As directed
Used for acute hypercalcemia or when nasal spray is not tolerated. Injection form is less commonly used for chronic osteoporosis.
Related Compounds
Research References
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy. Data is compiled from published research and regulatory sources and may not reflect the most recent developments.