GHRP-6
Category 1Also known as: Growth Hormone Releasing Peptide-6, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Growth Hormone SecretagogueLast reviewed: April 28, 2026
One of the original synthetic growth hormone secretagogues, developed in the 1980s. A hexapeptide that strongly stimulates GH release through ghrelin receptor activation. Historically significant as the compound that led to the discovery of the ghrelin receptor and the development of the entire GHS drug class.
Mechanism of Action
Binds to ghrelin receptors (GHS-R1a) in the pituitary and hypothalamus, triggering pulsatile GH release. Also stimulates appetite significantly through central ghrelin receptor activation — more so than most other GHS peptides. Increases IGF-1 levels downstream of GH release.
Common Uses
- Growth hormone optimization
- Muscle recovery and growth
- Fat loss
- Appetite stimulation (useful in wasting conditions)
- Anti-aging protocols
Known Risks
- Significant appetite stimulation (can undermine fat loss goals)
- Cortisol and prolactin elevation
- Water retention
- Desensitization with frequent dosing
- Tingling and numbness
- Limited long-term human safety data
Regulatory Status
Reclassified to Category 1 in February 2026 as part of the HHS announcement restoring compounding access. Not affected by the April 15, 2026 Category 2 removal action. Available through licensed 503A compounding pharmacies with a physician prescription. Often used in combination with GHRH analogs like CJC-1295.
Common Protocols
Protocol information is for educational reference only. Dosing varies significantly by individual, condition, and physician guidance. Always work with a licensed healthcare provider.
Subcutaneous injection
Typical Dose
100–300 mcg
Frequency
2–3x daily (before bed, morning, and optionally pre-workout)
Cycle Length
8–12 weeks on, 4 weeks off
Significant appetite stimulation — time doses away from meals you want to control. Often stacked with CJC-1295 (no DAC) for synergistic GH release. The appetite effect can be useful for those trying to increase caloric intake.
Related Compounds
Research References
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy. Data is compiled from published research and regulatory sources and may not reflect the most recent developments.