Kisspeptin
InvestigationalAlso known as: Kisspeptin-54, Kisspeptin-10, Metastin, KISS1
Hormonal & ReproductiveLast reviewed: April 28, 2026
A neuropeptide that acts as the master regulator of the reproductive hormone axis. Kisspeptin neurons in the hypothalamus control the release of GnRH (gonadotropin-releasing hormone), which in turn drives LH and FSH production. Increasingly studied for fertility treatment, hypogonadism, and as a diagnostic tool for reproductive disorders. Also being explored for its role in emotional and sexual brain processing.
Mechanism of Action
Binds to the KISS1R (GPR54) receptor on GnRH neurons in the hypothalamus, triggering GnRH release. This stimulates the anterior pituitary to release LH and FSH, which drive testosterone production in males and ovulation in females. Kisspeptin is the upstream 'gatekeeper' of the entire HPG axis.
Common Uses
- Fertility treatment (investigational)
- Hypogonadism evaluation
- IVF protocols (as GnRH trigger alternative)
- Reproductive endocrinology research
- Libido and sexual function research
Known Risks
- Injection site discomfort
- Headache and flushing
- Potential for ovarian hyperstimulation in women
- Short half-life requires frequent dosing or infusion
- Limited long-term safety data
Regulatory Status
Not FDA-approved. Active clinical trials at Imperial College London and other institutions for fertility applications. Being studied as a safer alternative to hCG triggers in IVF (lower risk of ovarian hyperstimulation syndrome). No US-approved formulation exists.
Common Protocols
Protocol information is for educational reference only. Dosing varies significantly by individual, condition, and physician guidance. Always work with a licensed healthcare provider.
Subcutaneous or intravenous injection
Typical Dose
1.0–6.4 nmol/kg (kisspeptin-54) or 0.3–1.0 nmol/kg (kisspeptin-10)
Frequency
Single dose or short infusion (clinical research setting)
Cycle Length
Single administration or short course
Currently used primarily in clinical research settings. The short half-life (~28 minutes for kisspeptin-54) limits practical therapeutic use outside of acute protocols like IVF triggers. Kisspeptin-10 is the shorter, more potent fragment. Not available from standard peptide suppliers.
Related Compounds
Research References
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy. Data is compiled from published research and regulatory sources and may not reflect the most recent developments.