Palmitoyl Pentapeptide-4
UnregulatedAlso known as: Matrixyl, Pal-KTTKS, Palmitoyl Pentapeptide
Cosmetic & SkinLast reviewed: April 28, 2026
A lipopeptide used in topical skincare that stimulates collagen and fibronectin production in the skin. One of the most studied cosmetic peptides, marketed as Matrixyl. Works by mimicking a collagen fragment that signals fibroblasts to produce new collagen matrix. Widely used in anti-aging serums and creams.
Mechanism of Action
The KTTKS sequence mimics a collagen breakdown fragment (matrikine) that signals fibroblasts to initiate new collagen synthesis. The palmitoyl group enhances skin penetration by increasing lipophilicity. Stimulates production of collagen types I, III, and IV, as well as fibronectin and glycosaminoglycans.
Common Uses
- Anti-wrinkle topical treatment
- Collagen stimulation in aging skin
- Skin firmness and elasticity improvement
- Post-procedure skin recovery
- Cosmeceutical formulations
Known Risks
- Generally well-tolerated topically
- Mild skin irritation in sensitive individuals
- Efficacy depends on formulation and concentration
- Not effective via injection — topical only
- Results require consistent use over weeks
Regulatory Status
Not regulated as a drug by the FDA. Classified as a cosmetic ingredient. No prescription required. Available in over-the-counter skincare products. No FDA review process for cosmetic peptides.
Common Protocols
Protocol information is for educational reference only. Dosing varies significantly by individual, condition, and physician guidance. Always work with a licensed healthcare provider.
Topical application
Typical Dose
Serum or cream containing 2–8% concentration
Frequency
Twice daily (morning and evening)
Cycle Length
Ongoing daily use
Apply to clean, dry skin before moisturizer. Results typically visible after 8–12 weeks of consistent use. Often combined with other peptides (copper peptides, SNAP-8) in multi-peptide serums. Look for products listing Palmitoyl Pentapeptide-4 in the first third of the ingredient list.
Related Compounds
Research References
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy. Data is compiled from published research and regulatory sources and may not reflect the most recent developments.