PEG-MGF
Pending PCACAlso known as: Pegylated Mechano Growth Factor, PEG-MGF, IGF-1Ec
Growth & RecoveryLast reviewed: April 28, 2026
A pegylated form of Mechano Growth Factor, a splice variant of IGF-1 produced in response to mechanical stress on muscle tissue. The PEG (polyethylene glycol) modification extends the half-life from minutes to hours. Studied for muscle repair, hypertrophy, and recovery from injury. One of the 12 peptides removed from Category 2 in April 2026.
Mechanism of Action
MGF is produced when muscle tissue is damaged or mechanically loaded. It activates satellite cells (muscle stem cells) and promotes their proliferation and differentiation into new muscle fibers. The PEG modification prevents rapid degradation, allowing sustained signaling. Works through the IGF-1 receptor but with distinct downstream effects from systemic IGF-1.
Common Uses
- Muscle repair and recovery
- Hypertrophy support
- Injury rehabilitation
- Age-related muscle loss (sarcopenia)
- Athletic recovery protocols
Known Risks
- Injection site pain and swelling
- Hypoglycemia risk
- Potential for uncontrolled cell proliferation
- Limited human safety data
- Banned by WADA in competitive sports
Regulatory Status
Removed from Category 2 on April 22, 2026. Scheduled for PCAC Group 2 review (by February 2027). Not FDA-approved for any indication. Previously restricted under Category 2 since September 2023.
Get notified when the PCAC decides on PEG-MGF
Scheduled review: 2027-02-01. We'll email you the same day results are announced.
Common Protocols
Protocol information is for educational reference only. Dosing varies significantly by individual, condition, and physician guidance. Always work with a licensed healthcare provider.
Intramuscular injection (localized)
Typical Dose
200 mcg per injection site
Frequency
2–3 times per week, post-workout
Cycle Length
4–6 weeks
Inject directly into the target muscle group immediately after training for localized satellite cell activation. Do not use systemically. Often cycled with IGF-1 LR3 (use PEG-MGF on training days, IGF-1 LR3 on rest days). Reconstitute with bacteriostatic water.
Related Compounds
Research References
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy. Data is compiled from published research and regulatory sources and may not reflect the most recent developments.