Thymosin Beta-4
UnregulatedAlso known as: Tβ4, Full-length TB4
Healing & RecoveryLast reviewed: April 28, 2026
The full-length 43-amino acid peptide from which TB-500 is derived. Thymosin Beta-4 is the most abundant member of the beta-thymosin family and plays a central role in tissue repair, cell migration, and anti-inflammatory signaling.
Mechanism of Action
Sequesters G-actin monomers, regulating actin polymerization critical for cell motility and wound healing. Promotes angiogenesis, reduces inflammation via NF-κB modulation, and supports stem cell differentiation. TB-500 is a synthetic fragment of the active region.
Common Uses
- Tissue repair and wound healing
- Cardiac tissue protection
- Corneal healing
- Anti-inflammatory support
- Hair regrowth
Known Risks
- Limited human clinical data for injectable form
- Theoretical oncogenesis concerns (promotes cell migration)
- More expensive than TB-500 fragment
- Injection site reactions
Regulatory Status
No FDA regulatory category for the full-length peptide. TB-500 (the fragment) is pending PCAC review. The full-length Thymosin Beta-4 is available only as a research chemical.
Common Protocols
Protocol information is for educational reference only. Dosing varies significantly by individual, condition, and physician guidance. Always work with a licensed healthcare provider.
Subcutaneous injection
Typical Dose
750 mcg–2 mg
Frequency
2–3x per week
Cycle Length
4–8 weeks
More potent than TB-500 fragment but also more expensive. Some practitioners prefer the fragment for cost-effectiveness. Reconstitute with bacteriostatic water.
Related Compounds
Research References
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy. Data is compiled from published research and regulatory sources and may not reflect the most recent developments.