Compare Peptides
Select any two compounds for a side-by-side comparison of mechanism, uses, risks, and FDA regulatory status.
Popular comparisons
A 32-amino acid peptide hormone produced by the thyroid gland that regulates calcium and bone metabolism. The salmon-derived form (sCT) is FDA-approved for osteoporosis and Paget's disease. One of the earliest peptide drugs.
A synthetic analog of parathyroid hormone-related protein (PTHrP) FDA-approved for osteoporosis. Similar to teriparatide but with a potentially more favorable bone-building to bone-resorbing ratio and lower hypercalcemia risk.
Binds to calcitonin receptors on osteoclasts, directly inhibiting bone resorption. Also has analgesic properties for bone pain through central nervous system mechanisms that are not fully understood. Salmon calcitonin is 40-50x more potent than human calcitonin.
Selectively activates the RG conformation of the PTH1 receptor, producing a more transient signaling response than teriparatide. This results in robust bone formation with less bone resorption and less calcium mobilization from bone.
- Postmenopausal osteoporosis
- Paget's disease of bone
- Hypercalcemia of malignancy
- Bone pain relief
- Postmenopausal osteoporosis
- Fracture risk reduction
- Bone density improvement
- Nasal irritation (nasal spray)
- Nausea
- Flushing
- Possible increased cancer risk with long-term use (FDA warning)
- Antibody formation reducing efficacy over time
- Osteosarcoma risk (boxed warning — animal studies)
- Dizziness
- Nausea
- Tachycardia
- Injection site reactions
- Limited to 2 years of use
FDA-approved as Miacalcin (injection, 1986; nasal spray, 1995) and Fortical (nasal spray). Largely superseded by bisphosphonates and newer agents for osteoporosis but still used for acute bone pain and Paget's disease.
FDA-approved as Tymlos (2017) for treatment of postmenopausal women with osteoporosis at high fracture risk. Limited to 2 years. Pen injector for daily self-administration.
This comparison is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy.