Compare Peptides
Select any two compounds for a side-by-side comparison of mechanism, uses, risks, and FDA regulatory status.
Popular comparisons
A 32-amino acid peptide hormone produced by the thyroid gland that regulates calcium and bone metabolism. The salmon-derived form (sCT) is FDA-approved for osteoporosis and Paget's disease. One of the earliest peptide drugs.
Bioactive peptide fragments derived from hydrolyzed collagen protein. The most commercially successful peptide supplement category, with a global market exceeding $5 billion. Available in Types I, II, III, and marine-sourced variants.
Binds to calcitonin receptors on osteoclasts, directly inhibiting bone resorption. Also has analgesic properties for bone pain through central nervous system mechanisms that are not fully understood. Salmon calcitonin is 40-50x more potent than human calcitonin.
Provides bioavailable proline, glycine, and hydroxyproline — amino acids critical for collagen synthesis. Dipeptides (Pro-Hyp, Hyp-Gly) are absorbed intact and stimulate fibroblast activity, promoting endogenous collagen production in skin, joints, and connective tissue.
- Postmenopausal osteoporosis
- Paget's disease of bone
- Hypercalcemia of malignancy
- Bone pain relief
- Skin elasticity and hydration
- Joint health and mobility
- Hair and nail strength
- Gut lining support
- Bone density support
- Nasal irritation (nasal spray)
- Nausea
- Flushing
- Possible increased cancer risk with long-term use (FDA warning)
- Antibody formation reducing efficacy over time
- Generally well-tolerated
- Mild GI discomfort in some users
- Allergic reactions (rare, especially marine-sourced)
- Heavy metal contamination risk in low-quality products
- Efficacy debated — some studies industry-funded
FDA-approved as Miacalcin (injection, 1986; nasal spray, 1995) and Fortical (nasal spray). Largely superseded by bisphosphonates and newer agents for osteoporosis but still used for acute bone pain and Paget's disease.
Classified as a dietary supplement under DSHEA. Not FDA-approved for any medical indication. Widely available OTC without prescription. No regulatory restrictions.
This comparison is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy.