Compare Peptides
Select any two compounds for a side-by-side comparison of mechanism, uses, risks, and FDA regulatory status.
Popular comparisons
GHRP-6
Growth Hormone Releasing Peptide-6, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
One of the original synthetic growth hormone secretagogues, developed in the 1980s. A hexapeptide that strongly stimulates GH release through ghrelin receptor activation. Historically significant as the compound that led to the discovery of the ghrelin receptor and the development of the entire GHS drug class.
A synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates the pituitary gland to produce more growth hormone. Available with or without a Drug Affinity Complex (DAC) that extends its half-life.
Binds to ghrelin receptors (GHS-R1a) in the pituitary and hypothalamus, triggering pulsatile GH release. Also stimulates appetite significantly through central ghrelin receptor activation — more so than most other GHS peptides. Increases IGF-1 levels downstream of GH release.
Binds to GHRH receptors on the pituitary gland, stimulating pulsatile release of growth hormone. The DAC version binds to albumin in the blood, extending the half-life from minutes to approximately 6-8 days.
- Growth hormone optimization
- Muscle recovery and growth
- Fat loss
- Appetite stimulation (useful in wasting conditions)
- Anti-aging protocols
- Growth hormone optimization
- Improved sleep quality
- Fat loss
- Muscle recovery
- Anti-aging protocols
- Significant appetite stimulation (can undermine fat loss goals)
- Cortisol and prolactin elevation
- Water retention
- Desensitization with frequent dosing
- Tingling and numbness
- Limited long-term human safety data
- Water retention
- Tingling or numbness
- Potential cortisol elevation
- Limited long-term safety data
- May affect blood sugar levels
Reclassified to Category 1 in February 2026 as part of the HHS announcement restoring compounding access. Not affected by the April 15, 2026 Category 2 removal action. Available through licensed 503A compounding pharmacies with a physician prescription. Often used in combination with GHRH analogs like CJC-1295.
Reclassified to Category 1 in February 2026 as part of the HHS announcement restoring compounding access. Not affected by the April 15, 2026 Category 2 removal action. Available through licensed 503A compounding pharmacies with a physician prescription.
- Growth hormone-releasing peptides and their analogs
1998 · PubMed
This comparison is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy.