Compare Peptides

Select any two compounds for a side-by-side comparison of mechanism, uses, risks, and FDA regulatory status.

Popular comparisons

Thymalin

Thymic peptide extract, Thymus extract

Unregulated
Immune & Longevity

Pinealon

EDR peptide, Glu-Asp-Arg

Unregulated
Nootropic & Neuroprotective
Overview

A thymic peptide bioregulator developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. Thymalin is a complex of polypeptides extracted from the thymus gland that has been used clinically in Russia since the 1980s for immune restoration. Khavinson's research group reported that thymalin treatment in elderly patients was associated with reduced mortality over a 6-year follow-up period.

A synthetic tripeptide (Glu-Asp-Arg) developed by the St. Petersburg Institute of Bioregulation and Gerontology — the same institution behind Epitalon. Pinealon is designed to target the central nervous system and pineal gland, with research focused on neuroprotection, cognitive function, and circadian rhythm regulation.

Mechanism of Action

Contains a mixture of thymic peptides that restore T-cell function and thymic output. Proposed to act through epigenetic mechanisms, reactivating genes involved in immune function that become silenced with aging. May promote thymic regeneration and restore the balance between T-helper and T-suppressor cells.

Penetrates the blood-brain barrier and accumulates in neurons. Modulates gene expression related to neuronal survival and function. Reduces oxidative stress in neural tissue. Appears to regulate melatonin synthesis through pineal gland activity, supporting circadian rhythm normalization.

Common Uses
  • Immune system restoration in elderly patients
  • Post-infection immune recovery
  • Anti-aging and longevity protocols
  • Adjunct to cancer immunotherapy (in Russian clinical practice)
  • Cognitive enhancement and memory
  • Neuroprotection
  • Sleep quality improvement
  • Age-related cognitive decline
  • Stroke recovery support (preliminary research)
Known Risks
  • Limited Western clinical data
  • Most research from Russian institutions — peer review concerns
  • Allergic reactions possible (animal-derived extract)
  • Quality varies significantly between sources
  • Very limited independent Western research
  • Most studies from Russian institutions
  • Long-term safety unknown
  • Mechanism not fully characterized
  • Injection site reactions
Regulatory Status
Unregulated

Not FDA-approved or recognized. Used clinically in Russia and some CIS countries. No FDA category. Available only as a research peptide in the US. Khavinson's longevity claims, while published, have not been replicated in Western clinical trials.

Unregulated

Not FDA-approved and not on any compounding list. Available as a research chemical. Research base is almost entirely from Russian institutions — independent replication is limited. Not affected by the 2026 regulatory changes.

This comparison is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy.