Compare Peptides
Select any two compounds for a side-by-side comparison of mechanism, uses, risks, and FDA regulatory status.
Popular comparisons
The full-length 43-amino acid peptide from which TB-500 is derived. Thymosin Beta-4 is the most abundant member of the beta-thymosin family and plays a central role in tissue repair, cell migration, and anti-inflammatory signaling.
A synthetic fragment of thymosin beta-4, a naturally occurring peptide involved in tissue repair and regeneration. Widely used in the biohacking community for injury recovery.
Sequesters G-actin monomers, regulating actin polymerization critical for cell motility and wound healing. Promotes angiogenesis, reduces inflammation via NF-κB modulation, and supports stem cell differentiation. TB-500 is a synthetic fragment of the active region.
Promotes cell migration, blood vessel formation, and reduces inflammation. Upregulates actin, a cell-building protein critical for healing and cell migration to injury sites.
- Tissue repair and wound healing
- Cardiac tissue protection
- Corneal healing
- Anti-inflammatory support
- Hair regrowth
- Muscle and tendon repair
- Wound healing
- Reducing inflammation
- Hair regrowth (emerging research)
- Cardiac tissue repair
- Limited human clinical data for injectable form
- Theoretical oncogenesis concerns (promotes cell migration)
- More expensive than TB-500 fragment
- Injection site reactions
- Limited human clinical data
- Potential tumor growth concerns (theoretical)
- Injection site reactions
- Headaches reported anecdotally
No FDA regulatory category for the full-length peptide. TB-500 (the fragment) is pending PCAC review. The full-length Thymosin Beta-4 is available only as a research chemical.
On April 15, 2026, the FDA announced TB-500 will be removed from the Category 2 'significant safety risks' list effective April 22, 2026. Scheduled for PCAC review on July 23, 2026 to determine eligibility for the 503A bulk drug substances list. Compounding pharmacies should exercise caution until PCAC takes action.
PCAC: July 23, 2026
- Thymosin β4 and its role in tissue repair
2012 · PubMed
- Thymosin β4 promotes dermal healing
2007 · PubMed
This comparison is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy.