Acetyl Hexapeptide-8
UnregulatedAlso known as: Argireline, Acetyl Hexapeptide-3, Ac-EEMQRR-NH2
Cosmetic & SkinLast reviewed: April 28, 2026
A synthetic peptide that inhibits neurotransmitter release at the neuromuscular junction, reducing muscle contraction and the appearance of expression lines. Often called 'topical Botox' in marketing, though the mechanism and potency differ significantly. One of the most commercially successful cosmetic peptides.
Mechanism of Action
Mimics the N-terminal end of SNAP-25, a protein essential for SNARE complex formation and neurotransmitter vesicle fusion. By competing with native SNAP-25, it partially inhibits acetylcholine release at the neuromuscular junction, reducing the intensity of muscle contractions that cause expression wrinkles.
Common Uses
- Forehead and crow's feet wrinkle reduction
- Expression line softening
- Preventive anti-aging skincare
- Botox-alternative topical treatment
- Periorbital wrinkle treatment
Known Risks
- Generally well-tolerated topically
- Much weaker effect than injectable Botox
- Skin irritation possible at high concentrations
- Efficacy debated — some studies show modest results
- Not effective via oral or injectable routes
Regulatory Status
Not regulated as a drug by the FDA. Classified as a cosmetic ingredient. Available over-the-counter in skincare products. No prescription required. The Ordinary and other brands sell 10% Argireline solutions.
Common Protocols
Protocol information is for educational reference only. Dosing varies significantly by individual, condition, and physician guidance. Always work with a licensed healthcare provider.
Topical application
Typical Dose
Serum containing 5–10% concentration
Frequency
Twice daily
Cycle Length
Ongoing daily use
Apply to expression line areas (forehead, around eyes, between brows) on clean skin. Often layered with other peptide serums. Results are subtle and cumulative — expect 4–8 weeks for visible changes. Not a replacement for Botox but can complement injectable treatments.
Related Compounds
Research References
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy. Data is compiled from published research and regulatory sources and may not reflect the most recent developments.