Human Beta-Defensin 2
UnregulatedAlso known as: HBD-2, hBD-2, DEFB4A
Immune & AntimicrobialLast reviewed: April 28, 2026
An antimicrobial peptide produced by epithelial cells in response to infection and inflammation. Part of the innate immune system's first line of defense. Research interest is growing for its potential in wound healing and anti-biofilm applications.
Mechanism of Action
Disrupts microbial cell membranes through electrostatic interaction with negatively charged phospholipids. Also acts as a chemoattractant for dendritic cells and T-cells, bridging innate and adaptive immunity. Upregulated by IL-1β, TNF-α, and bacterial components.
Common Uses
- Antimicrobial research
- Wound healing research
- Biofilm disruption
- Immune modulation research
Known Risks
- Research compound only — no human clinical use data
- Potential for immune overstimulation
- Stability challenges in formulation
- Cost-prohibitive for therapeutic use currently
Regulatory Status
No FDA regulatory category. Available only as a research reagent. No clinical trials for therapeutic use. Active area of academic research.
Common Protocols
Protocol information is for educational reference only. Dosing varies significantly by individual, condition, and physician guidance. Always work with a licensed healthcare provider.
Research use only
Typical Dose
N/A — research reagent
Frequency
N/A
Cycle Length
N/A
Not available for clinical use. Research applications include in vitro antimicrobial assays, wound healing models, and biofilm studies.
Related Compounds
Research References
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy. Data is compiled from published research and regulatory sources and may not reflect the most recent developments.