Lactoferrin
UnregulatedAlso known as: Lactotransferrin, LF, Apolactoferrin
Immune & AntimicrobialLast reviewed: April 28, 2026
A naturally occurring iron-binding glycoprotein found in milk, saliva, tears, and mucosal secretions. One of the body's first-line innate immune defenses. Available as an oral supplement and in research-grade injectable form.
Mechanism of Action
Binds free iron, depriving bacteria of a nutrient essential for growth (bacteriostatic effect). Also directly disrupts bacterial cell membranes (bactericidal). Modulates immune response by promoting T-cell and NK cell activity while reducing inflammatory cytokines. Enhances iron absorption in the gut.
Common Uses
- Immune support
- Iron deficiency (improves absorption)
- Gut health
- Antimicrobial defense
- Anti-inflammatory support
Known Risks
- Generally well-tolerated orally
- GI discomfort at high doses
- Allergic reactions in dairy-sensitive individuals
- Injectable form has limited safety data
Regulatory Status
Available as a dietary supplement (GRAS status). Not FDA-approved for any medical indication. Widely available OTC. Injectable form is research-only.
Common Protocols
Protocol information is for educational reference only. Dosing varies significantly by individual, condition, and physician guidance. Always work with a licensed healthcare provider.
Oral (capsule/powder)
Typical Dose
200–600 mg
Frequency
1–2x daily
Cycle Length
Ongoing
Take on empty stomach for immune support. With food for iron absorption. Bovine lactoferrin is the most studied form.
Related Compounds
Research References
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy. Data is compiled from published research and regulatory sources and may not reflect the most recent developments.