Epithalon (Injectable Form)
Pending PCACAlso known as: Epitalon Injectable, AEDG Injectable, Ala-Glu-Asp-Gly SC
Anti-Aging & LongevityLast reviewed: April 28, 2026
The injectable subcutaneous form of the Epithalon tetrapeptide, offering higher bioavailability than oral or nasal routes. Same active sequence (Ala-Glu-Asp-Gly) as oral Epitalon but delivered via injection for more reliable absorption. Studied for telomerase activation, pineal gland function, and circadian rhythm regulation.
Mechanism of Action
Same mechanism as oral Epitalon — stimulates telomerase activity in somatic cells, potentially slowing telomere shortening. Also modulates pineal gland melatonin production and may influence circadian rhythm regulation. The injectable route bypasses GI degradation, providing more consistent peptide delivery to target tissues.
Common Uses
- Anti-aging and longevity protocols
- Telomere maintenance (investigational)
- Sleep quality improvement
- Circadian rhythm regulation
- Pineal gland support
Known Risks
- Injection site reactions
- Drowsiness (melatonin-related)
- Limited human clinical data
- Long-term safety unknown
- Theoretical cancer risk from telomerase activation (unproven)
Regulatory Status
Shares regulatory status with Epitalon. Removed from Category 2 on April 22, 2026. Scheduled for PCAC Day 2 review on July 24, 2026. Not FDA-approved for any indication.
Get notified when the PCAC decides on Epithalon (Injectable Form)
Scheduled review: 2026-07-24. We'll email you the same day results are announced.
Common Protocols
Protocol information is for educational reference only. Dosing varies significantly by individual, condition, and physician guidance. Always work with a licensed healthcare provider.
Subcutaneous injection
Typical Dose
5–10 mg per injection
Frequency
Once daily for 10–20 days
Cycle Length
10–20 day course, repeated every 4–6 months
The Khavinson protocol uses 10 mg daily for 10 days, repeated every 6 months. Inject subcutaneously in the abdominal area. Reconstitute with bacteriostatic water. Some practitioners combine with Pinealon for synergistic pineal gland support. Evening administration may enhance melatonin-related effects.
Related Compounds
Research References
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy. Data is compiled from published research and regulatory sources and may not reflect the most recent developments.