MGF
UnregulatedAlso known as: Mechano Growth Factor, IGF-1Ec, Non-PEGylated MGF
Growth & RecoveryLast reviewed: April 28, 2026
A splice variant of IGF-1 produced in response to mechanical stress on muscle tissue. Plays a key role in muscle repair by activating satellite cells. The non-PEGylated form has a very short half-life.
Mechanism of Action
Activates muscle satellite (stem) cells, promoting their proliferation and differentiation into new muscle fibers. This is distinct from IGF-1's general anabolic effects — MGF specifically targets the repair response to mechanical damage.
Common Uses
- Muscle repair after injury
- Hypertrophy support
- Recovery from intense training
- Localized tissue repair
Known Risks
- Very short half-life (minutes)
- Must be injected locally at target site
- Limited human data
- Potential for uneven growth if injection technique is poor
- Theoretical cancer risk (promotes cell proliferation)
Regulatory Status
No FDA regulatory category. Available only as a research chemical. Not approved for any clinical indication.
Common Protocols
Protocol information is for educational reference only. Dosing varies significantly by individual, condition, and physician guidance. Always work with a licensed healthcare provider.
Intramuscular injection (local)
Typical Dose
100–200 mcg
Frequency
Post-workout, 2–3x per week
Cycle Length
4–6 weeks
Must inject directly into target muscle immediately post-training. Very short half-life — PEG-MGF is the longer-acting alternative. Often stacked with IGF-1 LR3.
Related Compounds
Research References
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy. Data is compiled from published research and regulatory sources and may not reflect the most recent developments.