Palmitoyl Tripeptide-1
UnregulatedAlso known as: Pal-GHK, Palmitoyl Oligopeptide, Biopeptide CL
Cosmetic & SkinLast reviewed: April 28, 2026
A lipopeptide consisting of palmitic acid linked to the GHK tripeptide sequence. Designed for topical use to stimulate collagen synthesis and skin repair. Often combined with Palmitoyl Tetrapeptide-7 in the commercial product Matrixyl 3000.
Mechanism of Action
Mimics the skin's natural collagen-fragment signaling. When collagen breaks down, GHK fragments signal fibroblasts to produce new collagen. Palmitoyl Tripeptide-1 amplifies this signal, promoting collagen I, III, and IV synthesis. The palmitic acid tail enhances skin penetration.
Common Uses
- Anti-aging skincare
- Collagen stimulation
- Wrinkle reduction
- Skin firmness
- Scar healing support
Known Risks
- Generally well-tolerated topically
- Rare skin irritation
- Efficacy varies by formulation concentration
- No injectable safety data
Regulatory Status
Cosmetic ingredient. Not FDA-regulated as a drug. Widely available in skincare products without prescription.
Common Protocols
Protocol information is for educational reference only. Dosing varies significantly by individual, condition, and physician guidance. Always work with a licensed healthcare provider.
Topical (serum/cream)
Typical Dose
Product-dependent (typically 100-500 ppm)
Frequency
Once or twice daily
Cycle Length
Ongoing
Most effective in combination with Palmitoyl Tetrapeptide-7 (Matrixyl 3000). Apply to clean skin before moisturizer. Results typically visible after 8-12 weeks.
Related Compounds
Research References
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy. Data is compiled from published research and regulatory sources and may not reflect the most recent developments.