Compare Peptides
Select any two compounds for a side-by-side comparison of mechanism, uses, risks, and FDA regulatory status.
Popular comparisons
A newer copper-binding tripeptide related to GHK-Cu but with a different amino acid sequence (Ala-His-Lys vs Gly-His-Lys). Emerging research suggests it may have distinct and potentially complementary effects on hair growth and skin rejuvenation.
A lipopeptide used in topical skincare that stimulates collagen and fibronectin production in the skin. One of the most studied cosmetic peptides, marketed as Matrixyl. Works by mimicking a collagen fragment that signals fibroblasts to produce new collagen matrix. Widely used in anti-aging serums and creams.
Binds copper ions similarly to GHK-Cu but activates different signaling pathways. Appears to stimulate Wnt/β-catenin signaling in hair follicle dermal papilla cells, promoting hair growth through a mechanism distinct from GHK-Cu's wound healing pathway.
The KTTKS sequence mimics a collagen breakdown fragment (matrikine) that signals fibroblasts to initiate new collagen synthesis. The palmitoyl group enhances skin penetration by increasing lipophilicity. Stimulates production of collagen types I, III, and IV, as well as fibronectin and glycosaminoglycans.
- Hair growth stimulation
- Skin rejuvenation
- Anti-aging
- Wound healing support
- Anti-wrinkle topical treatment
- Collagen stimulation in aging skin
- Skin firmness and elasticity improvement
- Post-procedure skin recovery
- Cosmeceutical formulations
- Very limited research compared to GHK-Cu
- Most studies are in vitro
- Potential copper toxicity at high doses
- Not well-characterized safety profile
- Generally well-tolerated topically
- Mild skin irritation in sensitive individuals
- Efficacy depends on formulation and concentration
- Not effective via injection — topical only
- Results require consistent use over weeks
No FDA regulatory category. Available as a research chemical and in some cosmetic formulations. Not subject to the same regulatory scrutiny as GHK-Cu injectable.
Not regulated as a drug by the FDA. Classified as a cosmetic ingredient. No prescription required. Available in over-the-counter skincare products. No FDA review process for cosmetic peptides.
This comparison is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide therapy.